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About Angiopoietin-2 (Ang-2)
Angiopoietin-2, full name of Ang-2, normally known as ANGPT2 or Ang-2, is a member of the angiopoietin family and is one of the angiogenic factors specifically expressed by endothelial cells. Angiogenesis is the process of generating new blood vessels and is involved in various physiological processes such as embryogenesis, wound healing, and tumorigenesis. Angiogenesis is tightly controlled in vivo and is usually regulated by a dynamic balance of pro- and anti-angiogenic factors and has a complex signaling pathway. In pathological states, this equilibrium is disturbed, angiogenic mechanisms go uninhibited, and hyperplasia of blood vessels occurs. Ang-2 is another important angiogenic factor identified after vascular endothelial growth factor (VEGF), which is involved in physiological and pathological angiogenesis and is associated with tumors, atherosclerosis, asthma, rheumatoid and other diseases. Some studies have shown that abnormal Ang-2 expression is closely associated with ocular diseases. Currently, faricimab (Roche), a bispecific antibody against Ang-2 for ocular use, has made significant progress in the treatment of retinal diseases such as neovascular age-related degeneration (AMD) and diabetic macular edema (DME) and has been approved for marketing by the FDA. In addition, ANG2 can induce the reactivation of vascular endothelial cells, triggering the process of angiogenesis, which is associated with a variety of diseases except for eye diseases, the most serious of which is tumor formation and tumor angiogenesis.
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